Bill..........Safety isn't an issue with me. The reason i'm a lefty is I lost the sight in my right eye. I'm really a RH shooter. I have to wear a patch on my right eye full time, so using a RH gun is actually safer for me.
I can also cock the hammer easily with my left thumb. So, that's a non issue too.
The cheek piece is my only issue, and that's also a non issue with guns that don't have them.
One advantage of using a RH gun is it's much much easier to sell. I had to practically give away a LH GPR flintlock I had.