I primarily use scopes on my wheel guns, they are all zeroed in at 100 yds. My go to is the Smith 629 hand loaded with Swift 240 gr A-Frames.
The Ruger SRH .454 is hand loaded with 300 gr A-Frames, and the Smith 500 is hand loaded with Hornady 350 gr XTP Mags.
I limit myself to 40 yds. when using open sights, I use a Ruger BH 45LC hand loaded with 250gr Barnes or 265gr LBT solids.
I have no problem squeezing a bit past 100 yds. “ A Man's Got to Know his Limitations”

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a little pic heavy...