There are a bunch of great calibers out there for hunting deer. I guess a lot of it may depend of where you hunt, the yardage you will be shooting and the size of your deer. I live in South Carolina and my average shot is 250 - 300 yards. I have shot many calibers my my old favorite is a Rem. model 700 .308 caliber. I have a good bit of custom work done do it such as trigger pull, floating the barrell, stock work etc... My wife shoots a .270 and she loves it. Good Luck!! -- CDH