My opinion is based on somewhat limited experience.

I tried hard cast 250 grain Lead Bullet Technology (LBT) WFN (Wide Flat Nose) bullets in my .41 Mag Ruger Bisley, shooting them at 1250 fps. (Picture Below) The gun wears a 2X Leupold pistol scope and would keep that load into 5-shot groups of less than 5" at 100 yards from a rest, and under 2" at 50 yards.

The perfect deer load, right? Well yes - but.

if I shot to break the shoulders the deer was down and kicking, usually dieing fairly quickly. But on heart/lung shots it punched through with modest (but deadly) internal damage. The deer usually traveled quite a ways after a heart/lung shot with small entry/exit holes.

I don't care for those bone breaking shoulder shots. Switched to Speer 210 grain Deep Curls and results with heart/lung shots were much more to my liking, with a good size exit hole and lots of bleeding. Sometimes they would drop at the shot. But more often they would run. But they don't go far and leave a good blood trail.