A question you will get 20 answers for!!! I have some big magnums that I love. however if I were to do it over and pick one it would be a 300wsm and a brake. There is a lot of ammo on the shelf for these compared to others. If you reload, all the better!!!! Yes, an 06 a .270 and .308 can all get it done. Just personal preference!!! I shoot a 7 ultra and a 30-378. I have to reload!! Love both guns and have made some long damaging shots. But I think I would go with the 300wsm. Still may own one!!!lol I shoot quite a bit and it sure would be cheaper. My buddy and nephew each own one and I am damn impressed.