Thanks for the input guys. I've narrowed down my options some, but haven't made a final decision yet. I got the results back from an MRI on my shoulder and I don't think a bow is going to happen at this time. And besides, I don't know that I could put down my muzzleloaders anyway. I know for sure I'm going to switch to .45. For me the benefits of a .45 outweigh a .50, and I checked the regs on any state that I would hunt in the near future and a .45 is legal for deer or elk.
Now I just have to decide within that. I have a little time so we'll see what happens.