This is a very interestin thread to me. I am right handed but I have to shoot left handed due to blindness in my right eye. I can see a few fuzzy lights or shadows out of the right so when I'm shooting I close the right eye. For me it is like turning the radio volume down so you can hear someone talking. It's a train of thought thing. Everyone always told me to shoot with both eyes open but it didn't work for me. My suggestion is to try different ways and see what works for you.