I have taken three deer, I believe, with the 300 grain S/Ws in my Omega. I used the 250 SSTs this year and they both performed the same on deer. They are very accurate, at least for me, out of my Omega. I have taken three deer with 240 XTPs (.452) and they were accurate and deadly as advertised as well. As stated many times before by many people, pretty much any accurately placed bullet is going to work.