Zero at 100 would be my game, even if I'm only shooting 50yrds. It'll be essentially ON at 50yrds still (100% good enough to kill any deer), and that way if you do need to take a 100yrd shot, it's on.

Even a .30-30 will shoot flat enough that you don't need to adjust your hold over for anything between 0-150yrds if you have a 100yrd zero.