Jeez, Todd, dunno.

I've used a lot of different muzzleloading bullets, and none of them have hit like the Hammer of Thor.

300-grain all copper Red Hots have consistently penetrated an entire animal for me, but I also have never had to track one more than ten yards - - if shot through the shoulder they drop like rocks, and when gut shot (I hate to admit it), they've laid down because they've been pretty much disemboweled.

I don't know if you can really do much better than good shot placement, assisted by complete penetration.