If you're a handloader the .260 makes sense. If not then I would go with the 25-06. I have a custom 25-06 & with handloads can pretty much cover all the game I hunt. Some use it on elk with good results but I wouldn't use it or the .260 for elk or larger critters. You already have the .300 Weath. for that. There are alot more factory loads for the 25-06 than exist for the .260. You can even find std. Remington Core-Lokts at Wal Mart for the 25-06 but I've yet to see any .260 ammo at Wal Mart. The only .260 loads I commonly see are the 140 gr Core-Lokt. With online ordering available I'm sure finding ammo is easy.