Personally I'm not that big of a fan of either. I had to carry the 220 for quite a while at the last place I worked. It shot fine. Of coarse the first shot on double action was a long stroke and then it went to light short strokes in single action. I just wasn't happy with the capacity and the first trigger pull. They do point and very shoot good though.

With the 21 I carried a gen 2 without the finger grooves, so the newer ones might have a different feel. It wasn't anything special, just a big hunk of gun in your hand. Didn't shoot good or bad for me, just adequate. I have big hands and for what ever reason the big grip just left a whole lot to be desired. I normally can shoot 100's with a pretty tight group for qualification. With the 21 it would be basketball size, so just adequate. The big grip was the culprit because I carry a 23 now and it has tight groups.

If you are hunting a 45 the springfield xdm is a pretty good one. They feel pretty good in the hand for a double stack mag and are really accurate. I don't carry one for work but have one at home for bowling pen matches. You may also want to look into the 40 cal options, not knowing what your plan for it is? Jou can get a lot slimmer pistols without sacrificing capacity while still maintaining adequate power. I like the 22 personally for carry but they issue a 23 and 27 at work and they do pretty decent even with the reduced sight radius.