I use the Burris Ballistic Plex reticle; zeroed at 100 yards.
See attached;
http://www.burrisoptics.com/pdf/BALLPLEX.pdf
Depending on the caliber and bullet weight; Burris supplies a "chart" corresponding to the bullet drop at the next line down (200 yards) and so on.
Each "line", again depending on caliber and bullet weight gives the bullet drop; if not exact, then says +1" or -2".
There is only one way to verify that; so using that as a base-line I confirm POI at the range for each (using the same ammo I use in the field).
Since I'm not a real bright guy; I have the same scope on all my bolt guns (one exception - I use a 24X Mil-dot on my .204).
I have a different ammo box for each of the calibers I use and tape the corresponding "chart" on the inside cover.
Works for me................ as I originally suggested, the window of opportunity opens and closes so quickly that I need to "dumb it down" as much as possible.
Always the same scope, always the same adjustments, always the same sight picture - the only thing that changes is the caliber of the gun I have in my hands.
As I said; I'm not a real bright guy and not a "sniper" either.