It all depends on what you are going to use it for.
I started big game hunting when I was in college and was living in NW Colorado. Back then the locals thought a .270 Win or .30-06 was perfect for mule deer and elk hunting, so my first centerfire rifle was a .30-06.
My .30-06 worked fine for several years of hunting mule deer, elk, and pronghorn antelope in Colorado and also for several years of hunting those same animals when I moved to Montana.
Then I met a new friend that had more than one rifle. He had a .22-250 for varmints, a .243 Win for deer, and a 7mm Rem mag for elk and larger animals. He also gave me a .30 Gibbs case, which I thought was very cool.
I carried that .30 Gibbs case in my pocket for several months, and finally had a local gunsmith re-chamber my .30-06 to .30 Gibbs. That was going to be my elk and other large animal rifle. And like my friend, I decided that I needed a varmint rifle and a deer rifle. I had also seen a tapered octagon barrel on a custom rifle at a gunshow, so I had my gunsmith make me a tapered octagon barrel in .22-250 and put it in a Mauser Mark X action for me. I had also been reading PO Ackley's books, so I had my gunsmith re-chamber another Mark X barreled action to .257 Ackley Improved which was to be my deer size critter rifle.
That all happened about 35 years ago, and I thought I had a perfect battery of rifles for all of my hunting. My .22-250 was great on varmints and I even used it on a few deer and pronghorn antelope. My .257 AI also worked on varmints, was great for deer and antelope, several bighorn rams and a Dall ram, a caribou, and a large 6x6 bull elk. My .30 Gibbs kept my freezers full of elk meat for almost 30 years, and also made one shot kills on a couple of Shiras moose bulls and a mountain goat.
Then about 15 years ago some friends of mine bought a South African plains game hunt at a Safari Club dinner and asked me to join them. Problem was I was going through a very nasty divorce and I couldn't have my guns, so one of my friends let me use his 7mm Rem mag in Africa. I liked that rifle so much that after my divorce was final, I bought my own 7mm RM. I then used it on a Musk ox/caribou hunt in the Arctic and on another African hunt. It's a stainless barrel and action in a plastic stock so I keep it as a wet weather backup rifle for elk or whatever.
In 2004 I booked a Cape Buffalo hunt in Zimbabwe so I needed a .375 or larger rifle for that hunt. I was impressed with the ballistics of the .375 Rem Ultra mag, so I built one. I've used that rifle on two African hunts, and it worked great on everything from 30 lb Steenbucks to 1500 lb Buffalo and Eland. Here at home it's a safe queen.
Ever since I started big game hunting in the mid '60s, I've admired Weatherby rifles, and particularly the .300 Weatherby. About 5 years ago I saw a good deal on a .300 Weatherby Vanguard so I bought it. I re-stocked it in Fancy walnut and made a few other modifications, and it is fast becoming my favorite rifle. With Barnes TSX and TTSX bullets it's flat shooting, accurate, and has enough power for just about any animal in North America or any of the African plains game. It will be going to New Zealand with me next year.