I was mainly referring to the brass Lehigh 50-325s. Those are probably going to be a big challenge sabotless. Pure copper is more forgiving than alloys or brass and bullets like the Parkers BEs are about as easy as they get. The pure lead core and thin jacket responds well in this application. I think Nosler still uses pure lead cores in their sporting handgun line. I have some 250gr HPs i will be trying next.
I also prefer sabots in my ULA 50cal. It shoots well with reasonable loading effort. My Elite 45 loads ok too with sabots and shoots fine.
The Pacnor 45 and DISC 45 though will likely move to sabotless and i will buy a adjustable die to keep it as convenient as possible.