How much money do you want to spend??

If your talking about a SERIOUS hunting or competition rig you will probably have to spend at least 1000+ on a rifle and another 1000+ on a good tactical scope with some sort of range finding reticle. This would probably be the mininum and go up from there.

I think one of the most popular calibers right now to shoot is 6.5mm(.264). Alot of guys are shooting wildcats such as 6.5-284 Winchester, 6.5-300 WSM, 6.5-06...

here is a link where you can get some REALLY GOOD advice...

http://www.longrangehunting.com/