Please don't use a .22. I know we all do it sometimes, but not on any kind of a regular basis. You have to be within 40 yards with a .22, and then you have to take a head shot, which is a high risk shot anyway. I shot a yote last year in the head, skinned him out and the skull wasn't even cracked, the bullet was smashed flat on the surface of the skull, must have hit him just hard enough to kill him, but I wouldn't count on that very often. I'd use your .270 with really light, HARD bullets so that your entry and exit wounds are both pretty small.