A 100 yard shot at pronghorn would be unusual, but happens. A 300 yard shot is far more common. Last year my antelope shot was a bit over 300 yard using a 45 caliber Omega, and that worked well. On that day there was no breeze, so the smoker was up to the task. Any kind of breeze at all, makes killing with a smoker difficult, iffy, at them longer ranges.

Neither of these 50 Omega, are reliable at that range, and neither will be called upon to make a shot much over 200 yard, if that.

It is far more likely there is a breeze, than not, out on the prairie. Because chances are more likely there will be a breeze when hunting them pronghorn, this year i will be carrying a breech loader, if the state draws my name. The small, long 6.5 bullet with a high ballistic coefficient, flies so much better than any bullet i use in my muzzle loaders.