My bow shoots 418fps with 420gr arrow, not the makers specs, from crony. I bought such a fast bow for just the reason you suggest, avoiding problems with wounded game. Given the ideal shot I suggested above I'd take the 50yd shot, given the shot you suggest with brush ect in the way........I agree, the range gets shorter & shorter depending on what the individual situation is.
I"m in farm country in the southern lower, so shots are more often open & completely clear here. I understand such a shot may be rare indeed in some other locations. Which is part of what I hope to see from all responding.
I also practice a lot at 30-70yds & sometimes a few @ 80yds.