They (95 grain) are moving about 3100 feet per second at the muzzle which is a pretty hot for a deer bullet in a small caliber. If you are hand loading and you know most shots will be within 100 and certainly with 50, load it down a bit to about 2900-2800. Even with it loaded down, I'd keep it strictly CNS or behind the shoulder. the speed of the round is great however, meaning you can if you need to take longer shots. (1000 lbs of energy at 400 yds meets ethics imo) .close it behind the shoulder and watch as the bullet sprays the lungs and heart pulp in every direction, Might as well be sending 6mm grenades.