I'm a fan of the Ruger MK lll myself, it will take a 1400 lb steer right to it's knees, but.......... that's hitting it in the brain. I have Ruger 22/45 22lr and would not be afraid to use that for self defense but....... you have to be in check and shoot to make them count. Pro side of that if you are in check you can place them shots as fast as lighting. Being on the lightside it may not be that great for someone under the influence of some drug.

I think if your using a 380 acp why not bump it to a 9mm it's got more thump and recoil and noise is not a lot different than a 9mm. 380's come in more pocket sized features though I will give it that. And maybe more fitting for a woman's hand.

I'm still pro revolver for inexperienced shooters. S&W 38 Spl. Ladysmith is not a bad self defense tool for women and men. It's pocket sized and as simplistic as it gets. Just point and pull the trigger mama. If you need more than six to back someone off or take them down your in trouble. Reloading is the downfall for using a revolver for self defense.

I love my Kimber 45acp, Mama is getting one in a compact model and lots of training. Her biggest complaint is remembering the functions but range time might cure that.