rodwha, I no longer have any .50 round ball shooters even though they did well for me. But I've never personally shot a deer with a .50 ball beyond 60 yards or so.

I moved up to two .54s and one .58 ball shooters and feel comfortable out to 125 yards with them (though I've yet to shoot a deer that far with any of them). I would have confidence with a .50 ball out there at 100 yards with a well placed shot into the heart/lung region. Especially on smaller deer.