I have gone to the 300 wsm as my go to rifle for deer and Elk when the weather is so bad a 500 yard shot is unlikely. I have had excellent results with a lighter weight short action rifle.
I still have a .340 weatherby for those days when I feel nothing else will do.
the 300 is more than enough rifle for 99% of the hunting I do. I would feel a lot better with the 340 if I was around a bunch of Brown Bears.
Ballistics the 300 is about right for me and for any shot I would take.
the 270 is a great caliber but is a bit light for a longer shot for heavy skinned game. I am sure plenty of guys have used them and I am sure there are guys who had good results. there are just better choices available to me for the areas I hunt and the conditions I hunt in. I own and shot a .270 Weatherby just not all the time.
the 338 -180 gr, trick is not a game I am willing to play. A 180 gr. 338 bullet lacks the sectional density to do the work I require from a mid bore rifle.