If it comes to self protection nothing beats a double action revolver for those that are not that well versed in handgun shooting. You don't have to keep it locked and cocked. You don't have to take a safety off before firing. You don't have to extensively know the mechanics of the firearm to clear a jam or malfunction.

All a person with novice experience has to do with a double action revolver in the heat of the moment is pull the trigger. Simplicity can save your life. All these concealed carry instructors promoting semi auto's over revolvers to non experienced shooters have never been down that road themselves.

S&W .38 special Lady Smith would be my suggestion for your wife. Unless she's Jessie Duff.