I was considering buy a .22 Hornet also,as mentioned its easy on the hides/fur and is a nice low recoil Rifle to use!Right now I'm using a CZ model 527 .204 "Varmint" with the longer heavier barrel and it does a great job on Coyotes,it shoots flat and far and is easy on the large Predators such as Coyotes!This would also be a good Caliber (.204 Ruger)to consider.
Most of my shots on any Predator has been from 25 out to 125 yards at the most with only a few times where I have shot from 125-250 yards out!
If Your looking for a good Walking Predator Rifle the Savage is great,Ruger,Kimber or the CZ model 527 "American" which is lighter and easy to carry.The CZ's usually have their own type of rings and the "American" comes with free rings,it has a walnut stock,4 shell magazine and a trigger that can be pushed forward for a lighter pull!You can choose from several calibers on the CZ 527 Model also.