The 220 grain bullet is designed for larger game like moose or grizzly. The reason there's less meat damage is because the bullet isn't expanding much on a deer. There's no guarantee as to how a deer will react, but typically they'll travel farther before dropping, you'll get a smaller exit wound, and have less blood to follow. Then again you might drop everything in their tracks. Even the 180's are designed for larger game like an elk, I prefer 150 to 165 grain bullets for deer. Another great option for hunting in brushy areas is to load a 170 grain round nose 30-30 bullet and keep the velocity down to 2200 fps.