LOL RR!
I'd like to say my favorite is my Rem 700 VSSF in .22-250, but I've never killed one with it! Every time we actually go out "coyote" hunting, we never see any. The only yotes I've gotten (3) have been with my .280 while deer hunting.
My varmint gun is a tack driver though...it shot at 1 hole 5shot group at 100yds, and I killed a groundhog at 500yds

(that is saying somethting for me, I don't shoot alot at long range) Maybe someday I'll get a yote with it.