1 1/2"- 2" of MOA works out more like this using the 2" variation is easier with said group size pattern.

100 yards= 2" MOA
200 yards= 4" MOA
300 yards= 6" MOA
400 Yards= 8" MOA
500 Yards= 10" MOA

So between 300 and 500 yards you are getting to the point of you may or may not wound that animal. 10" becomes a large pattern and for a whitetail that's just about outside any true point of aim to hit the kill zone. Especially when you add in Barometric Pressure, Mirage and Wind. Okay all said and done that's the extreme because most don't shoot deer at those ranges. But is a guideline to know your limits. Not saying you still can't shoot those longer distances and still have a great outcome but the odds are stacking against you.

Most rifles will shoot better than 1 1/2" groups by changing ammo. You may have wanted to shoot 150gr bullets out of your 30-06 but maybe the rifling likes 180gr bullets better or vice versa. Reloaders have the advantage of creating sub MOA type groups by experimenting with loads until they achieve the close to perfect load.

My two favorite hunting rifles shoot 1/2"-3/4" groups at 100 yards that is sub MOA. And they will stay under 2" groups at 200 yards. To me that's acceptable accuracy for 500-600yard kill zone accuracy.
My varmint rifle shoots 3/4" at 200 yards. That's a close to perfect load for a standard rifle setup.

All that said 1 1/2"-2" groups at 100yds will take you to 200yd plus no problem. Don't think trying a neck shot at 250yards would be wise. Best way to know what your rifle is doing at further ranges is to shoot paper at the ranges you want to use in hunting situations. I've seen people shoot some pretty horrible groups at 100 yards take big game at 400 plus yards. I think some people shoot more instinctive and natural at a animal than they do paper. My dad is one of the best big game shots I've ever seen. Whether it's a running shot or a really long range shot that animal is going down. Put him on paper and he'll shoot 1 1/2-2" groups at 100 yards. He'll let me sight his rifle in and then test fire it because he knows I'm a better paper puncher and he's a better in the field shot. It's all good.