Wow...what a good question. I would guess it depends on what you want to use it for. If you're going to shoot competition or silhoutte the Anshutz is definately the way to go. If the competition is where speed and accuracy is required..the Ruger 10/22. And if you're going to be using it for plinking or hunting...ain't nothing wrong with the Savage .22 with Accutrigger.
The diminutive .22 is a fun gun. I think I have about 6 of them (I'd have to sit and count). You can pay less than $200 for one or over $1000. Some of the Coopers as previously posted are gorgeous rifles and will punch ragged holes in targets at 50 yds. But you pay for this dearly. Good luck.