One needs only to look at the performance of the old 45-70 and other sharps calibers to see that although speed kills so do slow as hell heavy bullets like 350-500 grain. Many a head of large and dangerous game animals have fell to the old black powder cast bullet firearms of years gone by. There are a long line of folks on in both camps here. To an extent, everyone is correct. In the end though.ITS ALL SHOT PLACEMENT. 22 hornet or 700 express. A good hunter who can place his shots well has taken every game animal on earth with the 7x57 mauser and the 303 british and 30-06. As for the original question, I have no use for any of the big magnums. If I ever do it would be the 300 WSM.in the Browning A-bolt with the Boss comp. I would load it with Winchester Fail Safes.