I've used 100 gr CoreLokts, PowerPoints, and Hi-Shoks in .243 on deer and pronghorn for years without any issue. I can't remember any animal I've taken needing a follow-up shot, nor any of them traveling out of sight from where they were first hit.

My experience with SGKs has not been so positive. Every single one of them I've connected to an animal has shed its jacket, particularly the 165 gr in .308 (used in a moderate load in a .30-06), but also the 300 gr .375. It hasn't mattered whether they've hit bone, or whether they've gone through tissue, they've all lost their jackets. For that reason alone, I've discontinued using them at all in my hunting loads, and never did bother trying them out on deer or pronghorn in the .243.

Of course, your experiences are likely to vary. And, not to say I'm not a fan of Sierra. I use SMKs exclusively in many of my target and some of my varmint loads.

Generally speaking though, I prefer a "pointed-soft-point" over a "hollow-point" for any meat hunting I do, with the exception of the .22LR.