Some find heavy recoil a problem and as a result don't practice as much as they should. As long as you can handle the recoil and blast, shoot what you want. Extra power, however, will not be a substitute for good shooting. A gutshot elk will travel just as far whether it's hit with a 375 H&H or a 30-06. You can't miss 'em fast enough to kill 'em. Also, be prepared to pay some premium prices for the ammunition to feed the magnums.