Not to sound like a smart a$$ ... but in my view the answer is the one that groups the best out of your set-up. Any of the factory loaded 12 ga. slug-gun loads will kill deer cleanoy out to 125+ yards. The trick is finding one that will group great and then understandiong the arc of the round. These slugs are relatively slow moving, poor flying, heavy projectiles that lose a lot of energy quickly. The arc is substantial. Once you have found a good grouping round, I suggest you zero at 100 yards and check it at 50-75-125 and 150.