In my case being limited to only a number of what I consider capablile center fire rifles for moose hunting... those being a Ruger M77 shooting a 150 grain 7mm mag Remington Core lock, or a 30-06 (and I used 220 grain ) which I did use once... Also I have a 7.7 model 99 Arisaka that shoots a Norma 165 grain boat tail that I am pretty sure would get the job done. But if the shooting was going to be close quarter I would use my White Ultra Mag .50 caliber muzzle loader shooting 110 grains of Triple Seven 2f powder and a 500 grain conical bullet. Get me with in 100 yards and you'd have a dead moose.