There's not much to an antelope. No mass no heavy bone structure. Then again after watching a friend shoot one with a 300 RUM 180gr Accubond at 200yds and it still got back up and ran off it does boil down to the shot placement. I told him he needed a bigger gun for antelope hunting and laughed. Honestly there's not many bullets that shouldn't work on an antelope. I would take a more positive expansion bullet over a heavy controlled expansion for antelope. TSX would not be on my list anywhere.