With the right sights you aim right at the target no mater what the range is.

I am a big fan of big heavy bullets paper patched and sized to fit the barrel exactly the way I want it to. On my new .451 load that 409 gr bullet has over 1000 foot pounds of energy at 200 yards. I am not a big fan of shooting the first shot past 150 yards. But if I had an animal hit and wanted to put another one in him I am planning to sight the rifle in out to at least 300 yards. Ron