It all depends on the rate of twist. I am stretching it with these bullets in the 1-30 twist.
Also it depends on what the person is trying to achieve. After shooting paper patched bullets I will never go back. Everyone has their favorite way to do things.

On my first Renegade I shot 410 gr Horady Great plains bullets. When they quite making them I panicked. I bought 25 boxes of them because I knew there would never be another bullet that shot like those. At this same time I was putting together my second Renegade 50 fast twist. I was kicking around the idea of the 500 S&W bullets but I knew from past experience with other bullets that were too small in diameter that they would probably not work. Then I had the idea to paper patch them.
Once I did that I quit shooting the first 50 that used the Hornadys. The only 50 I use now is the "hot Rod Renegade"

The thing I like about this combo is it is dependable. From season to season the load is the same and the sights never have to be moved.
So far I have not found the bullet combo yet in the 45's that match the 50 for dependability. I have got some great groups out of my 45's but they have been hit or miss at times. I think most of that has been inconstancy of the lead hardness. I have had the hardness tester for a couple years now. I have kept a accurate journal of the lead hardness and groups. This is the hardest I have tried and this is the first time I have started out with a bullet at .446 instead of taking a bullets that is .458 or .459 and taking it down to .446 Sizing that far down I don't think was helping groups. Ron