As the old saying goe "a snub nose .38 kills just as dead as a cannon". A well placed shot is more important than cal. I do love my .243, well, I love em all. Lets see, 30.30, 45/70, .243, .270, .44, yes, (even the old .44). I should be able to take just about any N/A big game animal.
Its all in what you like and can afford, thats what matters.