Energy transfer is not what kills deer or you could shoot them in the @$$ and the "Hydrostatic Shock wave" so many speak of would kill them just as quickly as a shot in the vitals. Bullets that don't exit tend to kill a little quicker because they are typically softer highly frangible bullets that expand to a larger diameter and do more damage to the tissue they passed through.

A Remington 45-70 300gr bullet has a muzzle energy listing of 1810 fp.
A Remington 243 100gr bullet has a muzzle energy listing of 1945 fp.

According to the people who tout this energy transfer stuff the 243 clearly has more stopping power at close range. I doubt seriously that a 100gr 243 bullet would pass completely through a large Kodiak brown bear. So you are certain to dump all of that rounds energy into him. You are being charged by a Kodiak brown bear. Which gun do you want in your hands, the 243 or the inferior 45-70. LOL!

There is the world of paper ballistics and then there is the real world. Large holes in vital organs kill. Energy transfer is important in regards to your toaster browning a slice of bread. It doesn't have much to do with hunting.