I love to shoot and experiment with many different bullets/sabots. However, when I go hunting I almost always load the 300 gr XTP .430 caliber. It just works and it is low cost compared to most offerings on the market.
By the way I made my longest ever shot on a deer (100 yards stepped off in the field) with the the 300 XTP. It was a complete pass through with a blood trail 4 feet wide and 35 yards long to where it dropped. That shot was 4 minutes after I shot one at 20 yards that feel over and never twitched. The darn bullet just works for me.