Down wind,
AA is right, a good Hvy barreled varmiter is a good option,I assume you are hunting out of a stand?
I have a .243 Remington Varmit Laminated rifle with a 26 in barrel,cut down for a youth for sale,3-9 x 40mm Burris scoppe,lee dot rectical and it' s for sale,no my wife said no it' s not.
I would go Ruger varmit 25-06,I' m tellin you can' t go wrong.

I would have mentioned the good Ol' 250-3000 but it is almost obsolete,but it is also a good .25 bore.