The .270 anyday. You know that song anything you can do I can do better? And I would advise against the rem 770. Know people who have them and hate them. There is a BIG difference in the 700 and the 770. Looks at the savage 111, TC venture, and marlin xs7. All in the same range and better guns IMO. Also I agree with the 22-250 over the 243. No better varmint gin than the .22-250. Very flat shooting round. I shot a coyote this summer with a rem 700 in 22-250 at 353 yards. Held it on his back and spined him. Live that round. We shoot hand loads with a 53 gr accu tip. Another great gun if you don't have your heart set on a bolt gun is the h&r line with the bull barrel. Everyone I have ever seen shoot was a flat out tack driver!