I usually will load on a clean barrel (after popping a couple of primers) and leave it loaded from Day 1 of gun/muzzy season until I shoot it (now this is normally only a few days of it being loaded). I'm sure I could do it longer, but I prefer it this way. The only way I will unload and load a fresh charge is if I was hunting in the rain/snow and have reason to suspect some moisture might have got in....