Last year I took a 170 pound 10 point buck with 80 grains T7 and a 185 Lehigh. The bullet hit no vital organs other than the liver, from what I could tell, but the buck just stumbled a few yards and collapsed. If legal, I wouldn't doubt that the 200 Lehigh or 195 Barnes with 100 - 120 grains of T7 or BH209 would work pretty good...