Well for me when I first got into ML I bought a .54 Renegade from a buddy who set me up with PRB over 95 grains of Pyrodex.
I went the opposite direction because while I'm not a small guy, honestly, that load just plain hurt after 8 or 10 shots!
I also had an inline, briefly & a whole other story, & immediately ramped up to the full magnum load of 150 gr(iirc?). WOW! Decided if I wanted to be kicked by a horse I could save on the powder and just walk down to the neighbor's pasture.
So now, I shoot 70-80 gr 777 under a PRB, enjoy it & don't flinch!

As an aside,until the ML bug bit 12 years ago I was never really a "gun guy" always preferring archery so I may be a little slow on the uptake here but just yesterday I finally realized something:

I took my old single shot, no name 20 ga shotgun out(love this gun I've had since 14 yrs old) to my range. Finally I understand about sabots!