Your thinking is right on the money shooter50.

With a normal practical hunting load, a round ball sighted in with a 100 yard zero will be somewhere between 2 to 3 inches high at 50 yards. You will find this occurs regardless of caliber (.45 @ 1800 fps, .50 @ 1700 fps, .54 @ 1650 fps or .58 @ 1600 fps).