I would definately go with something bigger. But if that's what you have now and don't wanna buy another rifle it's not impossible. But I would absolutely not make anything but a headshot! I'd go with the 22 mag over the 17 thats just me... No doubt a 22 mag will put down a yote at 100 yards if shot in the head. I'd just be iffy bout a body shot. Hard to say if it would do much damage, they're tougher than nails!