It would have to be the .223 and the 22-250. If just out having fun I would take my little Sako Vixen .223, if participating in a contest hunt I would use the Rem Mod 7 in 22-250. I have no need for anything larger, call them in and "most" shots will be under 50 yards. Granted some coyotes will hang up on you but even at 300 yards the .223 is more than gun.