The only time I would shoot 150 grains of pellets was if my rifle and projectile I picked were accurate with that load. I don't care about the distance. 10 yards to 200 yards. If it is accurate, then I would use it. But remember, some projectiles do not like powerful loads and preform better with less powder. So know your rifle, your accuracy, and your projectile.
I note a lot of the hunting "experts" in the shows and articles talk about.. With my 150 grain load of Pyrodex RS and a 250 grain Shockwave I would make this shot with ease. I always wondered how much of this was BS.
How many here shoot three pellets as their load? Not me.