If you're using proper shooting form, your hand isn't taking any recoil, regardless of the stock configuration.

Personally, after a long day of shooting, my wrist gets much more tired after shooting a traditional style stock. Thumbholes or "gooseneck" style stocks with steep wrists and near vertical pistol grips are much more ergonomic (which is why they're ALWAYS used on benchrest rifles, when shooters are more concerned with relaxed natural point of aim).

When shooting a "standard" stock, I typically don't throw my thumb over the top and I bundle my hand in front of the wrist/pistol grip, rather than torquing my wrist into an unnatural position.

Frankly, our handbones are BUILT to be parallel to our arm bones. Standard stock wrists contort them to nearly perpendicular to the forearm, which is unnatural. Thumbhole stocks with large palm swells are some of the most naturally positioned and comfortable shooting stocks designed.